Genetics reveals many breast cancer patients don't need chemo

Phyllis Laccetti a participant in the TailorX breast cancer study at her home in Ossining NY

The two most recent studies it is funding look at tomosynthesis - a newer breast imaging technique - versus standard-of-care 3D mammograms, and research on whether weight loss impacts breast cancer treatment and outcomes.

As of January 2018, there are more than 3.1 million women with a history of breast cancer in the U.S. This includes women now being treated and women who have finished treatment.

The study enrolled 10,273 women who had the most common type of breast cancer (hormone-receptor positive, HER2 negative) that had not spread to lymph nodes.

Baroness Delyth Morgna, chief executive of Breast Cancer Now, said: "We hope these practice-changing findings will now help refine our use of chemotherapy on the NHS".

"Hopefully lead us to a more molecular based treatment of breast cancer so eventually patients not need surgery or radiation instead take a pill from medicine and cure breast cancer", said Figueredo.

When she was selected for the trial in 2015, the Florida woman "had tennis ball-sized tumours in her liver and secondary cancers throughout her body". Researchers used it to estimate the risk that a cancer will come back based on 21 genes linked with breast cancer recurrence.

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The study validates the gene test in the modern era and also clears up a "gray zone" - how to treat women with scores that were not clearly prognostic, Burstein said.

You'd think if a patient diagnosed with breast cancer had the option of undergoing chemotherapy or safely going without it, the answer would be obvious.

The results are expected to spare as many as 70,000 women from the expensive procedure that comes with harsh side effects.

According to first author Joseph Sparano of Montefiore Medical Center in Bronx, New York, "any woman with early-stage breast cancer 75 or younger should have the test and discuss the results" with her doctor.

Patients under 50 with a score of up to 15 also do not need to undergo the treatment, the research concluded.

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"Now with these genomic tests, we are finding that we have multiple types of breast cancer, perhaps several dozen", said Brawley, "and we are being able to tailor our therapies to the type of breast cancer every woman has".

Dr. Butler recalls the study and local women who participated and believes it's a medical breakthrough in the treatment of breast cancer.

To find the answer, researchers randomly assigned more than 6,700 women with intermediate scores - 11 to 25 - to two groups. "He said the process 'shows how the immune cells already inside cancers may be switched on and made to work better".

He added that it was important that the federal government funded the study because the pharmaceutical industry has little interest in sponsoring trials that result in a reduction of treatment.

"It means that maybe 100,000 women in the United States alone do not require chemotherapy", Norton said.

"Oncologists have been getting much smarter about dialing back treatment so that it doesn't do more harm than good", said Steven Katz, a University of MI researcher who examines medical decision-making.

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