Analysis of trial data confirms anti-depressants are effective, researchers say

The drugs do work: anti-depressants should be given to a million more Britons, largest ever review claims

"Antidepressants are routinely used worldwide yet there remains considerable debate about their effectiveness and tolerability", said John Ioannidis of Stanford University in the United States, who worked on a team of researchers led by Andrea Cipriani of Britain's Oxford University. The creators take note of that the distinction might be on account of melancholy in youngsters is the outcome of various components or causes, and note that as a result of the more modest number of concentrates in youngsters there is extraordinary vulnerability around the dangers and advantages of utilizing any antidepressants for the treatment of sorrow in kids and teenagers.

Researchers from Oxford University analysed data from 522 separate trials involving 116,000 patients suffering from moderate to severe depression.

The worldwide study uncovered a range of outcomes, with some drugs proving more effective than others and some having fewer side effects.

The drugs do work: anti-depressants should be given to a million more Britons, largest ever review claims

"Of course, these type of studies can not look at individual differences, so can not inform us about the specific personal characteristics that make an individual more likely to respond in general, or to respond to one medication rather than another one".

Cipriani said, "This is the largest and most robust study ever in antidepressants, and we found good news that they work, and outweigh the side effects". Considering all trials, the between-antidepressant differences in odds ratios varied from 1.15 to 1.55 for efficacy and from 0.64 to 0.83 for acceptability. The least effective turned out to be Fluoxetine (Prozac), fluvoxamine (Faverin), reboxetine (Edronax) and trazodone (Desyrel).

Agomelatine, amitriptyline, escitalopram, mirtazapine, paroxetine, venlafaxine, and vortioxetine were found to be most effective, while fluoxetine, fluvoxamine, reboxetine, and trazodone were least effective.

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When looking at the acceptability of the treatments (the dropout rates per treatment) agomelatine, citalopram, escitalopram, fluoxetine, sertraline, and vortioxetine were the most tolerated. Overall, 9% of the trials included in this meta-analysis were considered as high-risk of bias, 73% as moderate and 18% as low. The choice will be need to made by doctor and patient'.

"I'm not saying all patients with depression should be treated with antidepressants-they should all be offered effective treatments".

'Medication should always be cnsidered alongside other options, such as psychological therapies, where these are available'. For adults with major depressive disorder, all antidepressants are more efficacious than placebo, according to research published online February 21 in The Lancet. "This turned out to be very important", wrote Kirsch in a 2014 paper.

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"Ultimately, the field requires different research strategies to identify response at the level of the individual patient, not just network meta-analysis with larger sample sizes".

Several authors disclosed financial ties to the pharmaceutical industry. Parikh reports funding from Assurex Health, Canadian Institutes of Health Research, James and Ethel Flinn Foundation and Ontario Brain Institute. He also holds minor equity in Mensante.

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